Exforge package insert pdf

Package insert template for simvastatin tablet brand or product name product name tablet 10mg product name tablet 20mg product name tablet 40mg product name tablet 80mg name and strength of active substances simvastatin 10mg. Exforge contains the besylate salt of amlodipine, a dihydropyridine calciumchannel blocker ccb. Norvasc 5 mg tablets amlodipine besylate equivalent to 5 mg of amlodipine per tablet are white, elongated octagon, flatfaced, beveled edged engraved with both norvasc and 5 on one side and plain on the other side and supplied as follows. Dailymed exforge amlodipine besylate and valsartan. Jun 12, 2019 a patient may be initiated on exforge if it is unlikely that control of blood pressure would be achieved with a single agent. The bioavailability of amlodipine besylate tablets is not altered by the presence of food. Highlights of prescribing information inability to. Highlights of prescribing information administration with. Coadministration of simvastatin with amlodipine increases the systemic exposure of simvastatin.

Lowering blood pressure may lower your risk of a stroke or heart attack. Single oral amlodipine maleate doses equivalent to 4 or more mg amlodipine kg or higher in dogs 11 or more times the maximum recommended human dose on a mgm 2 basis caused a marked peripheral. These highlights do not include all the information needed to use exforge hct safely and effectively. Amlodipine and valsartan contains the besylate salt of amlodipine, a dihydropyridine calciumchannel blocker ccb. Information for the user amlodipine 5 mg tablets amlodipine 10 mg tablets amlodipine besilate read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Exforge tablets contain two substances called amlodipine and valsartan. To facilitate gastric emptying fosamax oral solution should be followed by at least 2 ounces a quarter of a cup of water. Initiation of glucophageglucophage xr in patients with an egfr between 30 45 mlminute1. Exforge hct amlodipine, valsartan, hydrochlorothiazide tablets, for oral use. If additional blood pressure reduction is needed, increase the dose to hyzaar 10012. Exforge hct tablet 516025 mg containing 5 mg of amlodipine as amlodipine besylate, 160 mg of valsartan and 25 mg hydrochlorothiazide. Increase to 20 mg or decrease to 5 mg based on efficacytolerability. Jan 11, 2012 amlodipine has indications other than hypertension which can be found in the norvasc package insert. To help lower costs, some people who are already taking amlodipine and valsartan may switch to the combination drug exforge.

Do not freeze medicines unless required by package insert. No drugdrug interaction studies have been performed with skip to content. Some health conditions may make you more susceptible to the sideeffects of the drug. Absolute bioavailability has been estimated to be between 64 and 90%. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events. Tarka trandolaprilverapamil hydrochloride er tablets. Exforge amlodipine and valsartan high blood pressure. It can be used by itself or with other medicines to treat these conditions. Amlodipine and valsartan fda prescribing information. Exforgehct amlodipine, valsartan, hydrochlorothiazide tablets, for oral use initial u.

The usual initial antihypertensive oral dose of norvasc is 5 mg once daily with a maximum dose of 10 mg once daily. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for exforge amlodipine valsartan. Exforge, innamlodipinevalsartan european medicines agency. Amlodipine has indications other than hypertension which can be found in the norvasc package insert. May 26, 2019 havrix package insert pdf product monograph. An oral dose of 80 mg inhibits the pressor effect by about 80% at peak with approximately 30% inhibition persisting for 24 hours. Small, fragile, or elderly patients, or patients with hepatic in sufficiency may be started on 2. Discontinue glucophageglucophage xr if the patients egfr later falls below. Call the merck national service center at 18778884231 if you have any questions.

Find patient medical information for exforge oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Increased risk of suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants 5. Losartan potassium and hydrochlorothiazide tablets 10025 are yellow, tear drop shaped. Levitra is a phosphodiesterase 5 pde5 inhibitor indicated for the treatment of erectile dysfunction. Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. Videos demonstrating insertion and removal are available online for trained healthcare providers. Exforge fda prescribing information, side effects and uses. This leaflet does not take the place of talking with your doctor about your. No drugdrug interaction studies have been performed with exforge and other medicinal products. For most patients, the starting dose is 10 mg, up to once daily.

To facilitate delivery to the stomach and thus reduce the potential for esophageal irritation, a fosamax tablet should be swallowed with a full glass of water 68 ounces. Before taking exforge, let your doctor know if you have heart disease, liver disease, or any allergies. Both of these substances help to control high blood pressure. Trandolapril is a white or almost white powder with a molecular weight of 430. Co exforge tablet is used for blood pressure, hypertension, heart problem and other conditions. Amiodarone, amlodipine, ranolazine do not exceed 20 mg simvastatin daily lomitapide for patients with hofh, do not. After oral administration of therapeutic doses of amlodipine besylate tablets, absorption produces peak plasma concentrations between 6 and 12 hours. Jun 20, 2019 exforge is used to treat high blood pressure hypertension. As novartis continues to closely monitor the coronavirus situation, our primary concern is the health and safety of our associates and patients globally. Single oral doses of amlodipine maleate equivalent to 40 mg amlodipine kg and 100 mg amlodipine kg in mice and rats, respectively, caused deaths. Amlodipine and valsartan is a fixed combination of amlodipine and valsartan. For further blood pressure reduction add other antihypertensives see clinical studies 14. Valsartan is an angiotensin ii receptor antagonist.

Suspension this leaflet is part iii of a threepart product monograph. Exforge contains a combination of amlodipine and valsartan. Learn more about how to exforge is a ccbarb singlepill combination product. Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when coadministered. Losartan potassium and hydrochlorothiazide tablets 10012. Enbrel etanerceptinjection, for subcutaneous use enbrel etanercept for injection, for subcutaneous use initial u. No drugdrug interaction studies have been performed with exforge and other. Highlights of prescribing information these highlights do not include all the information needed to use enbrel safely and effectively. Valsartan has indications other than hypertension which can be found in the diovan package insert. An oral dose of 80 mg inhibits the pressor effect by about 80% at peak. Exforge novartis is a new drug combination of the calcium channel blocker, amlodipine, and the angiotensin ii receptor blocker, valsartan. Exforge tablets are formulated in 4 strengths for oral administration with a combination of amlodipine besylate, equivalent to 5 mg or 10 mg of amlodipine freebase, with 160 mg, or 320 mg of valsartan providing for the following available combinations. Your doctor will know if amlodipine besylate tablets are right for you. The full blood pressure lowering effect was achieved 2 weeks after being on the maximal dose of amlodipine, valsartan and hydrochlorothiazide tablets.

Product name strength ndc number status size te rating brand referance image not to scale details. Exforge package insert pdf published on december 23, 2019 by admin controlled with amlodipine 10 mg or valsartan mg alone or with exforge 5 mg mg. Exforge amlodipine and valsartan tablets label fda. Highlights of prescribing information nexplanon safely and. It is used to treat high blood pressure hy pertension and a type of chest. Norvasc is a type of medicine known as a calcium channel blocker ccb. This emedtv article contains more exforge warnings and precautions, and lists potential side effects or complications that may occur with the drug. Exforge 5 mg80 mg exforge 5 mg160 mg exforge 10 mg160 mg.

The maximum recommended dose of amlodipine, valsartan. Fdaapproved patient labeling patient information exforge xphorj amlodipine and valsartan tablets read the patient information that comes with exforge before you start taking it and each time you get a. Highlights of prescribing information these highlights do not include all the information needed to use lotrelsafely and effectively. The purpose of this site is to make the package inserts for south african medicines available to the public in electronic format. While holding the adapter in the package, place the vial adapter over the vial and press down firmly on the package until the adapter spike penetrates the vial stopper. See package insert for full prescribing information. Pdf exforge amlodipinevalsartan combination in hypertension. Data sources include ibm watson micromedex updated 28 feb 2020, cerner multum updated 2 mar 2020, wolters kluwer updated. Exforge and exforge hct are prescription medications for the treatment of high blood pressure.

Dosage recommendations for exforge typically vary from 5160 mg to 10320 mg, depending on the previous dose of amlodipine and valsartan that you were taking and the severity of your blood pressure. The package inserts are indexed in three different ways. May 15, 2015 the pi is different from the patient package insert ppi, which contains information intended for patients, notwithstanding that the ppi may be required as part of the fdaapproved labeling for the drug. When viagra 100 mg was coadministered with amlodipine 5 mg or 10 mg to hypertensive patients, the mean additional reduction on supine blood pressure was 8 mmhg systolic and 7 mmhg diastolic see warnings and precautions 5. Registration number of the medicine in the national drug registry of the. It works by relaxing the muscles of your heart and blood vessels. Exforge amlodipine and valsartan tablets, for oral use.

Severe hypersensitivity to milk proteins or demonstrated hypersensitivity to fluticasone. Fetal toxicity when pregnancy is detected, discontinue exforge as soon as possible. Valsartan inhibits the pressor effect of angiotensin ii infusions. The binding of nifedipine to voltagedependent and possibly receptoroperated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. Highlights of prescribing information these highlights do not include all the information needed to use exforge hct safely and effectively. The dosage may be increased after 2 weeks of therapy. Amlodipine besylate tablets are a type of medi cine known as a calcium channel blocker ccb. When used in pregnancy, drugs that act directly on the. The pi is different from the patient package insert ppi, which contains information intended for patients, notwithstanding that the ppi may be required as part of the fdaapproved labeling for the drug. The printed package leaflet of the medicinal product must state the name and. Highlights of prescribing information lotrelsafely. Peel back the cover from the clear plastic vial adapter package.

Exforge has been shown to be effective in lowering blood pressure. Kmem charts pdf airport charts z 062614 z 072414 d tpp airport diagram takeoff minimums alternate minimums. It is used to treat high blood pressure hypertension and a type of chest pain called angina. These benefits have been seen in controlled trials of antihypertensive drugs from a wide. If you are unsure of the necessary steps to safely insert andor remove nexplanon, do not attempt the procedure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. Highlights of prescribing information do not coadminister. Micardis hct tablets should not be removed from blisters until immediately before administration.

Read the patient information that comes with exforge before you start taking it and. Exforge 5 mg80 mg, 5 mg160 mg and 10 mg160 mg filmcoated tablets. Tarka tablets are formulated for oral administration, containing verapamil hydrochloride as a controlled release formulation and trandolapril as an immediate release formulation. Arc storage conditions update novartis pharmaceuticals. Dailymed exforge amlodipine besylate and valsartan tablet. Lotrel amlodipine besylate and benazepril hydrochloride capsules, for oral. Both amlodipine and valsartan lower blood pressure by reducing peripheral resistance, but calcium influx blockade and reduction of angiotensin ii vasoconstriction are. Exforge hct amlodipine, valsartan, hydrochlorothiazide is indicated for the treatment of hypertension, to lower blood pressure. Highlights of prescribing information these highlights do not include all the information needed to use zocor safely and effectively. Exforge package insert pdf controlled with amlodipine 10 mg or valsartan mg alone or with exforge 5 mg mg.

Benicar hct may be used alone, or in combination with other antihypertensive drugs. Exforge is usually given after other blood pressure medicines have been tried without success. This leaflet was checked and approved by the ministry of health in june 2015. Mar 09, 2020 exforge is a fixed combination of amlodipine and valsartan. Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Exforge amlodipine and valsartan is indicated for the treatment of hypertension, to lower blood pressure. Before using co exforge tablet, inform your doctor about your current list of medications, over the counter products e. Exforge package insert pdf posted on april 4, 2020 by admin controlled with amlodipine 10 mg or valsartan mg alone or with exforge 5 mg mg. Deplin tablets folic acid, when administered in daily doses above 800 mcg, may increase the amount of unmetabolized folic description less likely than folic acid to accelerate the growth of existing neoplasms. In patients taking glucophageglucophage xr whose egfr later falls below 45 mlmin1. The usual starting dose is exforge 5160 mg once daily in patients who are not volumedepleted. Micardis hct tablets are not recommended for patients with severe hepatic impairment see use in specific populations 8. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

In controlled clinical trials directly comparing amlodipine besylate n 1730 at doses up to 10 mg to placebo n 1250, discontinuation of amlodipine besylate because of adverse reactions was required in only about 1. It is soluble 100 mgml in chloroform, dichloromethane, and methanol. May 03, 2019 its empirical formula is c 24 h 29 n 5 o 3 and its molecular weight is 435. Amlodipine besylate is a white to pale yellow crystalline powder, slightly soluble in water and sparingly soluble in ethanol. Nov 17, 2019 adacel package insert pdf adacel is an adultadolescent formulation diphtheriatetanusacellular encephalopathy has resulted from the administration of any vaccine product. Highlights of prescribing information these highlights do not. See full prescribing information for complete boxed warning.